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How to Handle Fatigue on GLP-1 Medications (Without Giving Up)

How to Handle Fatigue on GLP-1 Medications (Without Giving Up)

So you’re tired. Really tired. GLP-1 medications can zap your energy in the first few weeks (or longer). Fatigue is one of the most common complaints from people taking meds like Ozempic, Wegovy, and Mounjaro … and it’s frustrating when you’re hoping to feel healthier, not more exhausted.

Why It Happens

These meds slow digestion, affect blood sugar, and change your appetite signals. Your body is working overtime to adjust. Hormonal shifts plus reduced calorie intake can all combine into one big energy slump.

What You Can Do

  • Eat small, balanced meals: protein, fiber, and complex carbs can help steady your energy.
  • Hydrate: even mild dehydration makes fatigue worse.
  • Gentle movement: short walks, stretching, or yoga can boost circulation and help you feel less sluggish.
  • Sleep hygiene: keep bedtime and wake-up time consistent, and limit screen time before bed.
  • Check with your doctor: sometimes fatigue signals a deeper issue, like vitamin deficiency or medication adjustments needed.

You’re Not Alone

Many people report that fatigue improves over time as their bodies adapt. Meanwhile, consider extra support … like SymptoGuard – designed to help GLP-1 users feel more like themselves again. 

Ready to feel better on your GLP-1?